Bot. Mag. 63: plate 3478. 1836.
Annuals, (10–) 20–80 cm (roots relatively thin, branching). Herbage loosely arachno-tomentose, unevenly glabrate or glabrescent. Stems single. Leaves progressively reduced distally; petiolate (petioles broadly winged); blades ovatelanceolate, 3–8 (–10) × (1–) 1.5–3 (–4) cm, bases tapered or ± truncate, margins dentate to subentire (mid leaves subsessile, lanceolate; distal subulate, bractlike). Heads (1–) 10–30 in corymbiform arrays. Calyculi of 2–8 bractlets (1–2+ mm). Phyllaries ± 13, (6–) 7–10 mm, tips green to grayish. Ray-florets ± 8; corolla laminae 8–15 mm. Cypselae hirtellous.
Phenology: Flowering early–mid spring.
Habitat: Open sandy or disturbed sites
Elevation: 100–800 m
Senecio ampullaceus has been reported for Arkansas and Missouri (St. Louis). It is similar to S. quaylei.